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Literature summary extracted from

  • Cao, J.; Lockwood, J.; Burn, P.; Shi, Y.
    Cloning and functional characterization of a mouse intestinal acyl-CoA: monoacylglycerol acyltransferase, MGAT2 (2003), J. Biol. Chem., 278, 13860-13866.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.22 expression of MGAT2 in AV-12, COS-7 and CACO-2 cell Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol Mus musculus the enzyme plays a predominant role in dietary fat absorption in the small intestine, where it catalyzes the first step of triacylglycerol resynthesis in enterocytes for chylomicron formation and secretion CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol Mus musculus MGAT2 may play an important role in dietary fat absorption CoA + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 adipose tissue
-
 Mus musculus
-
2.3.1.22 kidney MGAT2 Mus musculus
-
2.3.1.22 kidney highest expression of MGAT1 mRNA Mus musculus
-
2.3.1.22 liver low expression of MGAT2 Mus musculus
-
2.3.1.22 skeletal muscle low expression of MGAT2 Mus musculus
-
2.3.1.22 small intestine
-
 Mus musculus
-
2.3.1.22 stomach MGAT2 Mus musculus
-
2.3.1.22 stomach highest expression of MGAT1 mRNA Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol the enzyme plays a predominant role in dietary fat absorption in the small intestine, where it catalyzes the first step of triacylglycerol resynthesis in enterocytes for chylomicron formation and secretion Mus musculus CoA + diacylglycerol
-
 ?
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol MGAT2 may play an important role in dietary fat absorption Mus musculus CoA + diacylglycerol
-
 ?
2.3.1.22 additional information the enzyme catalyzes the acylation of rac-1-monoacylglycerol, sn-2-monoacylglycerol, and sn-3-monoacylglycerols, the enzyme prefers monoacylglycerols containing unsaturated fatty acyls Mus musculus ?
-
 ?
2.3.1.22 oleoyl-CoA + sn-2-monooleoylglycerol
-
 Mus musculus CoA + sn-1,2(2,3)-dioleoylglycerol
-
 ?