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Literature summary extracted from

  • Meegalla, R.L.; Billheimer, J.T.; Cheng, D.
    Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin (2002), Biochem. Biophys. Res. Commun., 298, 317-323.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.20 glucose treatment of adipocytes with glucose increases DGAT1 mRNA Mus musculus
2.3.1.20 Insulin treatment of adipocytes with insulin increases DGAT2 mRNA Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.20 membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.20 acyl-CoA + 1,2-diacylglycerol Mus musculus DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver CoA + triacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 3T3-L1 cell 3T3-L1 fibroblasts differentiated into adipocytes Mus musculus
-
2.3.1.20 adipocyte
-
 Mus musculus
-
2.3.1.20 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.20 0.0003
-
 membrane fraction after insulin-starvation Mus musculus
2.3.1.20 0.00036
-
 membrane fraction after carbohydrate-starvation Mus musculus
2.3.1.20 0.00265
-
 membrane fraction Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 acyl-CoA + 1,2-diacylglycerol DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver Mus musculus CoA + triacylglycerol
-
 ?