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Literature summary extracted from

  • Morillas, M.; Clotet, J.; Rubi, B.; Serra, D.; Arino, J.; Hegardt, F.G.; Asins, G.
    Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues (2000), Biochem. J., 351, 495-502.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.137 0.0002
-
 decanoyl-CoA
-
 Rattus norvegicus
2.3.1.137 0.0026
-
 decanoyl-CoA recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH340A/H131 Rattus norvegicus
2.3.1.137 0.006
-
 decanoyl-CoA recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH340 Rattus norvegicus
2.3.1.137 0.106
-
 L-carnitine recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH340A Rattus norvegicus
2.3.1.137 0.117
-
 L-carnitine recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH340A/H131 Rattus norvegicus
2.3.1.137 0.218
-
 L-carnitine
-
 Rattus norvegicus
2.3.1.137 160
-
 L-carnitine recombinant enzyme expressed in Saccharomyces cerevisiae pYESCOTH131A Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 peroxisome
-
 Bos taurus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Bos taurus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Bos taurus
-
 bovine
-
2.3.1.137 no activity in Saccharomyces cerevisiae
-
-
-
2.3.1.137 Rattus norvegicus P11466 SwissProt accession number U26033
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 heart
-
 Bos taurus
-
2.3.1.137 liver
-
 Bos taurus
-
2.3.1.137 pancreas
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine
-
 Bos taurus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 decanoyl-CoA + L-carnitine
-
 Rattus norvegicus L-decanoyl-L-carnitine + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 COT
-
 Bos taurus