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Literature summary extracted from

  • McGuire, D.M.; Tormanen, C.D.; Segal, I.S.; Van Pilsum, J.F.
    The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats (1980), J. Biol. Chem., 255, 1152-1159.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.4.1 glycine inhibits in presence of low amounts of arginine Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.4.1 1.8
-
 arginine
-
 Sus scrofa
2.1.4.1 2.3
-
 glycine
-
 Sus scrofa
2.1.4.1 2.4
-
 arginine beta-transamidinase Rattus norvegicus
2.1.4.1 2.8
-
 arginine alpha-transamidinase Rattus norvegicus
2.1.4.1 3
-
 glycine alpha-transamidinase Rattus norvegicus
2.1.4.1 3.1
-
 glycine beta-transamidinase Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.4.1 42000
-
 2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE Rattus norvegicus
2.1.4.1 44000
-
 2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE Rattus norvegicus
2.1.4.1 82600
-
 alpha-transamidinase, sedimentation equilibrium Rattus norvegicus
2.1.4.1 83000
-
 gel filtration Rattus norvegicus
2.1.4.1 83300
-
 beta-transamidinase, sedimentation equilibrium Rattus norvegicus
2.1.4.1 100000
-
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.4.1 L-arginine + glycine Rattus norvegicus
-
 L-ornithine + guanidinoacetate
-
 r
2.1.4.1 L-arginine + glycine Sus scrofa
-
 L-ornithine + guanidinoacetate
-
 r
2.1.4.1 L-ornithine + guanidinoacetate Sus scrofa
-
 L-arginine + glycine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.4.1 Rattus norvegicus
-
 rat
-
2.1.4.1 Sus scrofa
-
 pig, porcine, hog
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.4.1 2 fractions of enzyme, designated alpha- and beta transamidase individually purified Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.4.1 kidney
-
 Sus scrofa
-
2.1.4.1 pancreas
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.4.1 0.34
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.4.1 canavanine + ornithine
-
 Rattus norvegicus arginine + canaline
-
 r
2.1.4.1 canavanine + ornithine
-
 Sus scrofa arginine + canaline
-
 r
2.1.4.1 L-arginine + glycine
-
 Rattus norvegicus L-ornithine + guanidinoacetate
-
 r
2.1.4.1 L-arginine + glycine
-
 Sus scrofa L-ornithine + guanidinoacetate
-
 r
2.1.4.1 L-ornithine + guanidinoacetate
-
 Sus scrofa L-arginine + glycine
-
 r

Subunits

EC Number Subunits Comment Organism
2.1.4.1 dimer
-
 Sus scrofa
2.1.4.1 dimer 2 * 42000, alpha-transamidinase, SDS-PAGE, 2 * 44000, beta-transamidinase, SDS-PAGE Rattus norvegicus