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Literature summary extracted from

  • Purcarea, C.; Erauso, G.; Prieur, D.; Herve, G.
    The catalytic and regulatory properties of aspartate transcarbamoylase from Pyrococcus abyssi, a new deep-sea hyperthermophilic archaeobacterium (1994), Microbiology, 140, 1967-1975.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.3.2 ATP
-
 Pyrococcus abyssi
2.1.3.2 N-(Phosphonoacetyl)-L-aspartate at concentrations below 0.001 mM Pyrococcus abyssi
2.1.3.2 succinate low concentrations, 35% activation in the presence of 2 mM aspartate Pyrococcus abyssi

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.3.2 CTP
-
 Pyrococcus abyssi
2.1.3.2 additional information 50% inhibition at 80 MPa; not inhibited by phosphonoacetate, diphosphate or phosphate Pyrococcus abyssi
2.1.3.2 N-(Phosphonoacetyl)-L-aspartate 0.011 mM, 50% inhibition, low concentrations activate Pyrococcus abyssi
2.1.3.2 UTP
-
 Pyrococcus abyssi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.3.2 additional information
-
 additional information sigmoidal saturation curve for carbamoylphosphate and aspartate Pyrococcus abyssi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.3.2 carbamoylphosphate + L-aspartate Pyrococcus abyssi
-
 phosphate + N-carbamoyl-L-aspartate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.3.2 Pyrococcus abyssi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.3.2 ion-exchange, gel filtration Pyrococcus abyssi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.3.2 carbamoyl phosphate + L-aspartate
-
 Pyrococcus abyssi phosphate + N-carbamoyl-L-aspartate
-
 ?
2.1.3.2 carbamoylphosphate + L-aspartate
-
 Pyrococcus abyssi phosphate + N-carbamoyl-L-aspartate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.3.2 90
-
 no loss of activity after 6 h Pyrococcus abyssi

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.3.2 9
-
-
 Pyrococcus abyssi