EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.2.3 | medicine | attractive anticancer target | Gallus sp. |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.2.3 | ATIC complex crystallized in monoclinic space group P2(1), a = 56.48 A, b = 107.88 A, c = 103.86 A and beta = 91.2° | Gallus sp. |
2.1.2.3 | crystallized in a binary complex with methotrexate, single crystal at 96 K to 2.3 A resolution, monoclinic crystals, space group P2(1), with unit-cell dimensions a = 65.17, B = 105.93, c= 103.47 A, beta = 108.27 degrees | Gallus sp. |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Gallus sp. | penultimate and final steps in the de novo purine biosynthesis pathway | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Gallus sp. | - |
avian | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.1.2.3 | recombinant avian ATIC, purified from E. coli expression system | Gallus sp. |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | penultimate and final steps in the de novo purine biosynthesis pathway | Gallus sp. | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
2.1.2.3 | additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Gallus sp. | ? | - |
? | |
2.1.2.3 | N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Gallus sp. | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (AICAR Tfase)-inosine monophosphate cyclohydrolase | - |
Gallus sp. |
2.1.2.3 | ATIC | - |
Gallus sp. |
2.1.2.3 | IMPCH | - |
Gallus sp. |