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Literature summary extracted from

  • Smith, G.K.; Mueller, T.; Benkovic, P.A.; Benkovic, S.J.
    On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver (1981), Biochemistry, 20, 1241-1245.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.2.3 0.0679
-
 10-formyltetrahydrofolate
-
 Gallus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide Gallus sp. reduced folate cofactor requiring step of de novo purine biosynthesis tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Gallus sp.
-
 chicken
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.3 liver
-
 Gallus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyl-8-deazafolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide
-
 Gallus sp. 8-deazafolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide reduced folate cofactor requiring step of de novo purine biosynthesis Gallus sp. tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide
-
 r
2.1.2.3 additional information in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene Gallus sp. ?
-
 ?
2.1.2.3 N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide
-
 Gallus sp. tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide
-
 r