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Literature summary extracted from

  • Malygin, E.G.; Ovechkina, L.G.; Evdokimov, A.A.; Zinoviev, V.V.
    Single turnover kinetics of methylation by T4 DNA-(N6-adenine)-methyltransferase (2001), Mol. Biol., 35, 56-68.
No PubMed abstract available

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.72 Tequatrovirus T4
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine various synthetic oligonucleotide substrates. Upon collision of an enzyme monomer with an oligonucleotide duplex, an asymmetrical complex forms in which the enzyme (randomly oriented relative to one of the strands of the specific recognition site) catalyzes a fast transfer of the methyl group from S-adenmosylmethionine to the adenosine residue. Simultaneously, a second T4MTAse subunit is added to the complex, providing for the continuation of the reaction Tequatrovirus T4 S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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2.1.1.72 S-adenosyl-L-methionine + DNA adenine synthetic oligonucleotide substrates containing the native recognition site GATC or its modified variants Tequatrovirus T4 S-adenosyl-L-homocysteine + DNA 6-methylaminopurine
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.72 T4DNA-(N6-adenine)-methyltransferase
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 Tequatrovirus T4

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.72 additional information
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 additional information turnover-numbers of synthetic oligonucleotide substrates containing the native recognition site GATC or its modified variants Tequatrovirus T4