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Literature summary extracted from

  • Lee, M.W.; Bakovic, M.; Vance, D.E.
    Overexpression of phosphatidylethanolamine N-methyltransferase 2 in CHO-K1 cells does not attenuate the activity of the CDP-choline pathway for phosphatidylcholine biosynthesis (1996), Biochem. J., 320, 905-910.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine Cricetulus griseus expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.17 Cricetulus griseus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.17 ovary cell line cells express only a trace amount of phosphatidylethanolamine N-methyltransferase. Transfection of CHO cells, ovary cell line MT58, with PEMT2 cDNA behind the cytomegalovirus promoter result in a series of cell lines that overexpress PEMT2 Cricetulus griseus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine
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 Cricetulus griseus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
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2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase Cricetulus griseus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
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 ?