Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ridgway, N.D.; Vance, D.E.
    Phosphatidylethanolamine N-methyltransferase from rat liver (1992), Methods Enzymol., 209, 366-374.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.17 additional information phosphatidylethanolamine, monomethyl-phosphatidylethanolamine and dimethyl-phosphatidylethanolamine compete for a common active site Rattus norvegicus
2.1.1.17 S-adenosylhomocysteine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.17 0.016
-
 S-adenosylmethionine reaction with phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
2.1.1.17 0.022
-
 S-adenosylmethionine reaction with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
2.1.1.17 0.08
-
 phosphatidyl-N-methylethanolamine
-
 Rattus norvegicus
2.1.1.17 0.45
-
 phosphatidyl-N,N-dimethylethanolamine
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.17 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.1.1.17 microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.17 18300
-
 1 * 18300, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.17 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.17
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.17 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.17 0.63
-
 activity with phosphatidylethanolamine Rattus norvegicus
2.1.1.17 3.75
-
 activity with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
2.1.1.17 8.59
-
 activity with phosphatidyl-N,N-dimethyl-ethanolamine Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.17 2 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine ordered bi-bi mechanism Rattus norvegicus 2 S-adenosyl-L-homocysteine + phosphatidylcholine
-
 ?
2.1.1.17 S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 Rattus norvegicus S-adenosyl-L-methionine + phosphatidylethanolamin
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine ordered bi-bi mechanism Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
 ?
2.1.1.17 S-adenosyl-L-methionine + phosphatidylethanolamine transfer of three methyl groups to the amino head group of phosphatidylethanolamine Rattus norvegicus S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.17 monomer 1 * 18300, SDS-PAGE Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.17 additional information
-
 activity increases in nearly a linear fashion between pH 6.0 and 9.5 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.17 0.0049
-
 S-adenosyl-L-homocysteine reaction with phosphatidyl-N-monomethylethanolamine Rattus norvegicus
2.1.1.17 0.0067
-
 S-adenosyl-L-homocysteine reaction with phosphatidyl-N,N-dimethylethanolamine Rattus norvegicus
2.1.1.17 0.0739
-
 S-adenosylhomocysteine reaction with phosphatidyl-N-dimethylethanolamine Rattus norvegicus