EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.64 | when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens |
2.1.1.114 | when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens |
2.1.1.222 | when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.1.1.64 | 40998 | - |
x * 40998, calculated from sequence | Homo sapiens |
2.1.1.114 | 40998 | - |
x * 40998, calculated from sequence | Homo sapiens |
2.1.1.222 | 40998 | - |
x * 40998, calculated from sequence | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-10 | Homo sapiens | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10 | S-adenosyl-L-homocysteine + ubiquinol-10 + H+ | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 5-all-trans-decaprenyl-3,4-dihydroxybenzoate | Homo sapiens | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 5-all-trans-decaprenyl-3,4-dihydroxybenzoate and 2. the methylation of 3-demethylubiquinol-10 (this reaction is classified as EC 2.1.1.64) | S-adenosyl-L-homocysteine + 5-all-trans-decaprenyl-4-hydroxy-3-methoxybenzoate | - |
? | |
2.1.1.222 | additional information | Homo sapiens | the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114) | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.64 | Homo sapiens | Q9NZJ6 | - |
- |
2.1.1.114 | Homo sapiens | Q9NZJ6 | - |
- |
2.1.1.222 | Homo sapiens | Q9NZJ6 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.64 | heart | - |
Homo sapiens | - |
2.1.1.114 | heart | - |
Homo sapiens | - |
2.1.1.222 | heart | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.64 | additional information | wide substrate specificity. The enzyme methylates both eukaryotic substrates 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and demethylubiquinol-3 and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol | Homo sapiens | ? | - |
? | |
2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-10 | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10 | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-10 + H+ | - |
? | |
2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 | i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-3 | - |
? | |
2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-6 | 3-demethylubiquinol-6 is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (methylated by the yeast enzyme COQ3 to ubiquinol-6). The human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens | S-adenosyl-L-homocysteine + ubiquinol-6 | - |
? | |
2.1.1.114 | additional information | wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol | Homo sapiens | ? | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate | in vitro assay | Homo sapiens | S-adenosyl-L-homocysteine + 5-(2E,6E)-farnesyl-4-hydroxy-3-methoxybenzoate | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate | 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (that is methylated by the yeast enzyme CoQ3 to 4-hydroxy-3-methoxy-5-hexaprenylbenzoate). When expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast | Homo sapiens | S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate | - |
? | |
2.1.1.114 | S-adenosyl-L-methionine + 5-all-trans-decaprenyl-3,4-dihydroxybenzoate | the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 5-all-trans-decaprenyl-3,4-dihydroxybenzoate and 2. the methylation of 3-demethylubiquinol-10 (this reaction is classified as EC 2.1.1.64) | Homo sapiens | S-adenosyl-L-homocysteine + 5-all-trans-decaprenyl-4-hydroxy-3-methoxybenzoate | - |
? | |
2.1.1.222 | additional information | the enzyme is involved in biosynthesis of ubiquinone-10 in human and catalyzes the methylation of 3-demethylubiquinol-10 to ubiquinol-10 (EC 2.1.1.64) and the methylation of 3,4-dihydroxy-5-decaprenylbenzoate to 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate (EC 2.1.1.114) | Homo sapiens | ? | - |
? | |
2.1.1.222 | additional information | wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol | Homo sapiens | ? | - |
? | |
2.1.1.222 | S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol | i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol. The substrate is an artificial farnesylated analog of the Escherichia coli substrate 2-all-trans-octaprenyl-6-hydroxyphenol, an intermediate in the biosynthesis of ubiquinone-8 in Escherichia coli | Homo sapiens | S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol | i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol | ? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.1.64 | ? | x * 40998, calculated from sequence | Homo sapiens |
2.1.1.114 | ? | x * 40998, calculated from sequence | Homo sapiens |
2.1.1.222 | ? | x * 40998, calculated from sequence | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.64 | COQ3 | - |
Homo sapiens |
2.1.1.64 | Coq3 O-methyltransferase | - |
Homo sapiens |
2.1.1.114 | COQ3 | - |
Homo sapiens |
2.1.1.114 | Coq3 O-methyltransferase | - |
Homo sapiens |