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Literature summary extracted from

  • Klein, Z.; Ben-Baruch, G.; Marciano, D.; Solomon, R.; Altaras, M.; Kloog, Y.
    Characterization of the prenylated protein methyltransferase in human endometrial carcinoma (1994), Biochim. Biophys. Acta, 1226, 330-336.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 S-adenosyl-L-homocysteine
-
 Homo sapiens
2.1.1.100 S-Farnesylthioacetic acid
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.100 0.018
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine enzyme from endometrial carcinoma Homo sapiens
2.1.1.100 0.02
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine enzyme from endometrium Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.100 microsome
-
 Homo sapiens
-
-
2.1.1.100 mitochondrial membrane
-
 Homo sapiens 31966
-
2.1.1.100 nuclear membrane
-
 Homo sapiens 31965
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 endometrioid carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine 21000-24000 Da GTP-binding proteins Homo sapiens S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.100 0.002
-
 S-Farnesylthioacetic acid
-
 Homo sapiens