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Literature summary extracted from

  • Lovenberg, W.; Weissbach, H.; Udenfriend, S.
    Aromatic L-amino acid decarboxylase (1962), J. Biol. Chem., 237, 89-93.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.53 Benzene stimulates decarboxylation of natural amino acids Cavia aperea

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.53 5-hydroxytryptophan complete inhibition at 0.001 mM Cavia aperea
4.1.1.53 alpha-Methyl-3,4-dihydroxyphenylalanine competitive Cavia aperea
4.1.1.53 alpha-Methyl-5-hydroxyphenylalanine
-
 Cavia aperea
4.1.1.53 alpha-Methyl-m-tyrosine
-
 Cavia aperea
4.1.1.53 alpha-Methyltryptophan
-
 Cavia aperea
4.1.1.53 p-chloromercuribenzoate complete inhibition at 0.01 mM Cavia aperea

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.53 0.002
-
 5-hydroxytryptophan
-
 Cavia aperea
4.1.1.53 0.04
-
 3,4-dihydroxyphenylalanine
-
 Cavia aperea
4.1.1.53 0.3
-
 tryptophan
-
 Cavia aperea
4.1.1.53 1.3
-
 p-tyrosine
-
 Cavia aperea
4.1.1.53 2
-
 phenylalanine
-
 Cavia aperea
4.1.1.53 2.2
-
 histidine
-
 Cavia aperea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.53 additional information Cavia aperea involved in amine formation from natural amino acids prior to excretion ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.53 Canis lupus
-
 dog
-
4.1.1.53 Cavia aperea
-
 guinea pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.53
-
 Cavia aperea
4.1.1.53 brain stem enzyme, partial Canis lupus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.53 brain
-
 Canis lupus
-
4.1.1.53 kidney
-
 Cavia aperea
-
4.1.1.53 kidney
-
 Canis lupus
-
4.1.1.53 liver
-
 Cavia aperea
-
4.1.1.53 liver
-
 Canis lupus
-
4.1.1.53 stomach
-
 Cavia aperea
-

Storage Stability

EC Number Storage Stability Organism
4.1.1.53 3¦C, 0.03 M phosphate buffer, pH 7, 40% loss of activity after 10 days, purified enzyme Cavia aperea

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.53 3,4-Dihydroxyphenylalanine
-
 Cavia aperea Dopamine + CO2
-
 ?
4.1.1.53 3,4-Dihydroxyphenylalanine
-
 Canis lupus Dopamine + CO2
-
 ?
4.1.1.53 5-Hydroxytryptophan
-
 Cavia aperea Serotonin + CO2
-
 ?
4.1.1.53 5-Hydroxytryptophan
-
 Canis lupus Serotonin + CO2
-
 ?
4.1.1.53 Histidine
-
 Cavia aperea Histamine + CO2
-
 ?
4.1.1.53 Histidine
-
 Canis lupus Histamine + CO2
-
 ?
4.1.1.53 L-phenylalanine
-
 Cavia aperea phenylethylamine + CO2
-
 ?
4.1.1.53 L-phenylalanine
-
 Canis lupus phenylethylamine + CO2
-
 ?
4.1.1.53 L-Tyrosine
-
 Cavia aperea Tyramine + CO2
-
 ?
4.1.1.53 L-Tyrosine
-
 Canis lupus Tyramine + CO2
-
 ?
4.1.1.53 additional information involved in amine formation from natural amino acids prior to excretion Cavia aperea ?
-
 ?
4.1.1.53 Tryptophan
-
 Cavia aperea Tryptamine + CO2
-
 ?
4.1.1.53 Tryptophan
-
 Canis lupus Tryptamine + CO2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.53 37
-
 enzyme assay at Cavia aperea

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.53 9
-
-
 Cavia aperea

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.53 pyridoxal 5'-phosphate
-
 Cavia aperea
4.1.1.53 pyridoxal 5'-phosphate
-
 Canis lupus