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Literature summary extracted from

  • Timmers, R.J.M.; Lambert, J.G.D.
    Kinetic studies of catechol-O-methyltransferase from the brain of the African catfish, Clarias gariepinus (1988), Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol., 91, 399-402.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 Mg2+ required for activity Clarias gariepinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 0.0005
-
 dopamine
-
 Clarias gariepinus
2.1.1.6 0.0006
-
 Catecholestradiol
-
 Clarias gariepinus
2.1.1.6 0.0012
-
 Catecholestrone
-
 Clarias gariepinus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.1.1.6 Mg2+ required Clarias gariepinus
2.1.1.6 Mg2+ optimum 10 mM Clarias gariepinus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Clarias gariepinus
-
 African catfish
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 catecholestradiol + S-adenosyl-L-methionine
-
 Clarias gariepinus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 catecholestrone + S-adenosyl-L-methionine
-
 Clarias gariepinus S-adenosyl-L-homocysteine + ?
-
 ?
2.1.1.6 S-adenosyl-L-methionine + dopamine
-
 Clarias gariepinus S-adenosyl-L-homocysteine + 3-methoxytyramine
-
 r