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Literature summary extracted from

  • Sugden, D.; Cena, V.; Klein, D.C.
    Hydroxyindole O-methyltransferase (1987), Methods Enzymol., 142, 590-596.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.4 cytosol
-
 Gallus gallus 5829
-
2.1.1.4 cytosol
-
 Rattus norvegicus 5829
-
2.1.1.4 cytosol
-
 Bos taurus 5829
-
2.1.1.4 cytosol
-
 Ovis aries 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.4 76000 78000
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine Gallus gallus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine Rattus norvegicus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine Bos taurus formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine Ovis aries formation of the hormone melatonin S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.4 Bos taurus
-
-
-
2.1.1.4 Gallus gallus
-
-
-
2.1.1.4 Ovis aries
-
-
-
2.1.1.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.4
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Gallus gallus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Rattus norvegicus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Bos taurus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin reaction sequence is ordered bi-bi type Ovis aries
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Gallus gallus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Rattus norvegicus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Bos taurus
a
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin addition of S-adenosyl-L-methionine occuring first followed by N-acetylserotonin Ovis aries
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.4 pineal gland
-
 Gallus gallus
-
2.1.1.4 pineal gland
-
 Rattus norvegicus
-
2.1.1.4 pineal gland
-
 Bos taurus
-
2.1.1.4 pineal gland
-
 Ovis aries
-
2.1.1.4 retina
-
 Gallus gallus
-
2.1.1.4 retina
-
 Rattus norvegicus
-
2.1.1.4 retina
-
 Ovis aries
-

Storage Stability

EC Number Storage Stability Organism
2.1.1.4 4°C, 96 h, inactivated Rattus norvegicus
2.1.1.4 4°C, 96 h, pineal enzyme stable Bos taurus
2.1.1.4 4°C, 96 h, pineal enzyme stable Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Gallus gallus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Bos taurus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine formation of the hormone melatonin Ovis aries S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Gallus gallus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Bos taurus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?
2.1.1.4 S-adenosyl-L-methionine + N-acetylserotonin
-
 Ovis aries S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?