Literature summary extracted from

Wright, L.S.; Bertics, P.J.; Siegel, F.L.
Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors (1996), J. Biol. Chem., 271, 12737-12743.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.60	Calmidazolium	-	Rattus norvegicus
2.1.1.60	S-adenosylhomocysteine	-	Rattus norvegicus
2.1.1.60	trimethyllysine calmodulin	-	Rattus norvegicus
2.1.1.60	VU-3 Calmodulin	-	Rattus norvegicus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.1.1.60	0.00023	-	mushroom demethylcalmodulin	-	Rattus norvegicus
2.1.1.60	0.002	-	S-adenosyl-L-methionine	-	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.60	Escherichia coli	-	-	-
2.1.1.60	Rattus norvegicus	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
2.1.1.60	S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine	Bi Bi sequential mechanism	Rattus norvegicus	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.60	testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.60	S-adenosyl-L-methionine + calmodulin L-lysine	-	Escherichia coli	S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine	-	?
2.1.1.60	S-adenosyl-L-methionine + calmodulin L-lysine	mushroom demthylcalmodulin	Rattus norvegicus	S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine	trimethyllysine calmodulin, major product, + dimethyllysine + monomethyllysine	?
2.1.1.60	S-adenosyl-L-methionine + mushroom demethylcalmodulin	-	Rattus norvegicus	?	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.1.1.60	0.00031	-	trimethyllysine calmodulin	-	Rattus norvegicus
2.1.1.60	0.0004	-	VU-3 Calmodulin	-	Rattus norvegicus

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Release 2023.1 (January 2023)