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Literature summary extracted from

  • Lacza, Z.; Puskar, M.; Figueroa, J.P.; Zhang, J.; Rajapakse, N.; Busija, D.W.
    Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia (2001), Free Radic. Biol. Med., 31, 1609-1615.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 Calmidazolium calmodulin antagonist; complete inhibition Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Mus musculus
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ Mus musculus C57BL/6
-
 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Mus musculus
-
-
-
1.14.13.39 Mus musculus C57BL/6
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 brain
-
 Mus musculus
-
1.14.13.39 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.39 0.000009
-
 liver mitochondria Mus musculus
1.14.13.39 0.000017
-
 liver Mus musculus
1.14.13.39 0.000033
-
 brain mitochondria Mus musculus
1.14.13.39 0.00054
-
 brain Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Mus musculus 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Mus musculus C57BL/6 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 32
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.39 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin
-
 Mus musculus
1.14.13.39 FAD
-
 Mus musculus
1.14.13.39 FMN
-
 Mus musculus
1.14.13.39 NADPH
-
 Mus musculus