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Literature summary extracted from

  • Garcia-Pascual, A.; Costa, G.; Labadia, A.; Persson, K.; Triguero, D.
    Characterization of nitric oxide synthase activity in sheep urinary tract: functional implications (1996), Br. J. Pharmacol., 118, 905-914.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 7-nitroindazole weak inhibition Ovis aries
1.14.13.39 L-canavanine not inhibitory Ovis aries
1.14.13.39 Ngamma-monomethyl-L-arginine slightly Ovis aries
1.14.13.39 Ngamma-nitro-L-arginine
-
 Ovis aries
1.14.13.39 Ngamma-nitro-L-arginine methyl ester
-
 Ovis aries
1.14.13.39 NO feedback inhibition Ovis aries

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.39 0.0091
-
 L-arginine detrusor Ovis aries
1.14.13.39 0.0099
-
 L-arginine urethra Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.39 cytosol
-
 Ovis aries 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.39 Ca2+ required Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 detrusor
-
 Ovis aries
-
1.14.13.39 ureter
-
 Ovis aries
-
1.14.13.39 urethra
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.13.39 additional information
-
 activity in urinary tract tissues Ovis aries

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 4 O2 + 3 H+
-
 Ovis aries 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.13.39 37
-
 assay at Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin
-
 Ovis aries
1.14.13.39 Calmodulin required Ovis aries
1.14.13.39 NADPH
-
 Ovis aries