EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | nitroblue tetrazolium | - |
Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.13.39 | 0.008 | 0.0084 | dichlorophenolindophenol | - |
Sus scrofa | |
1.14.13.39 | 0.016 | - |
nitroblue tetrazolium | - |
Sus scrofa | |
1.14.13.39 | 0.0323 | 0.035 | L-arginine | cytochrome c reduction | Sus scrofa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | Ca2+ | the enzyme bears Ca2+/calmodulin dependent cytochrome P-450 reductase activity which catalyzes cytochrome c reduction | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.39 | additional information | Sus scrofa | NO represents the endogenous activator of soluble guanylyl cyclase | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.39 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.13.39 | - |
Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.39 | brain | - |
Sus scrofa | - |
1.14.13.39 | cerebellum | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.13.39 | 0.01 | - |
reductase activity | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.39 | 2 L-arginine + 3 NADPH + 4 O2 + 3 H+ | - |
Sus scrofa | 2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O | the product is a guanylyl-cyclase-relaxing factor, that is identical with nitric oxide or a NO-releasing compound | ? | |
1.14.13.39 | 2,6-dichlorophenolindophenol + NADPH + O2 | - |
Sus scrofa | ? + NO + NADP+ | - |
? | |
1.14.13.39 | additional information | the reductase domain has a broad substrate specificity, catalyzes a moderate Ca2+/calmodulin independent hydroxylation when the enzyme is reconstituted with purified P-450 | Sus scrofa | ? | - |
? | |
1.14.13.39 | additional information | NO represents the endogenous activator of soluble guanylyl cyclase | Sus scrofa | ? | - |
? | |
1.14.13.39 | nitroblue tetrazolium + 2 NADPH | - |
Sus scrofa | nitroblue tetrazolium formazan + 2 NADP+ | - |
? | |
1.14.13.39 | oxidized cytochrome c + NADPH + O2 | reaction is enhanced by addition of calmodulin at 0.0002 mM | Sus scrofa | reduced cytochrome c + NADP+ + H2O | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.13.39 | 37 | - |
assay at | Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | 2,6-dichlorophenolindophenol | activation | Sus scrofa | |
1.14.13.39 | 5,6,7,8-tetrahydro-L-biopterin | - |
Sus scrofa | |
1.14.13.39 | Calmodulin | the enzyme bears a Ca2+/calmodulin dependent FAD and FMN containing reductase domain which transfers electrons from NADPH to a variety of acceptors | Sus scrofa | |
1.14.13.39 | cytochrome c | activation | Sus scrofa | |
1.14.13.39 | FAD | the enzyme bears Ca2+/calmodulin dependent FAD and FMN containing reductase domain which transfers electrons from NADPH to a variety of acceptors | Sus scrofa | |
1.14.13.39 | FMN | the enzyme bears Ca2+/calmodulin dependent FAD and FMN containing reductase domain which transfers electrons from NADPH to a variety of acceptors | Sus scrofa | |
1.14.13.39 | NADPH | - |
Sus scrofa | |
1.14.13.39 | nitroblue tetrazolium | activation | Sus scrofa |