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Literature summary extracted from

  • Neary, J.T.; Soodak, M.; Maloof, F.
    Iodination by thyroid peroxidase (1984), Methods Enzymol., 107, 445-475.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.8 Aminotriazole
-
 Sus scrofa
1.11.1.8 azide
-
 Bos taurus
1.11.1.8 azide
-
 Rattus norvegicus
1.11.1.8 azide
-
 Sus scrofa
1.11.1.8 cyanide
-
 Bos taurus
1.11.1.8 cyanide
-
 Rattus norvegicus
1.11.1.8 cyanide
-
 Sus scrofa
1.11.1.8 thiouracil
-
 Sus scrofa
1.11.1.8 Thiourea weak Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.8 membrane integral membrane protein Rattus norvegicus 16020
-
1.11.1.8 membrane integral membrane protein Bos taurus 16020
-
1.11.1.8 microsome
-
 Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.8 additional information
-
 different molecular weights found after different preparation procedures Sus scrofa
1.11.1.8 additional information
-
 different molecular weights found after different preparation procedures Bos taurus
1.11.1.8 135000
-
 gel filtration, Triton solubilized enzyme Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.8 iodide + H2O2 Rattus norvegicus iodination and coupling reactions of proteins iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2 Sus scrofa iodination and coupling reactions of proteins iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2 Bos taurus iodination and coupling reactions of proteins iodine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.8 Bos taurus
-
-
-
1.11.1.8 Rattus norvegicus
-
-
-
1.11.1.8 Sus scrofa
-
 pig, female
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.11.1.8 glycoprotein
-
 Rattus norvegicus
1.11.1.8 glycoprotein
-
 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.8
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.8 thyroid gland
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11.1.8 138
-
 purified enzyme with guaiacol as substrate Sus scrofa
1.11.1.8 464
-
 with guaiacol as substrate Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.11.1.8 -20°C, 4 years, no loss of activity Sus scrofa
1.11.1.8 -70°C, several months, no loss of activity of partially purified enzyme Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.8 guaiacol + H2O2 + I-
-
 Sus scrofa tetraguaiacol + H2O
-
 ?
1.11.1.8 guaiacol + H2O2 + I-
-
 Bos taurus tetraguaiacol + H2O
-
 ?
1.11.1.8 iodide + H2O2
-
 Rattus norvegicus iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2
-
 Sus scrofa iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2
-
 Bos taurus iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2 iodination and coupling reactions of proteins Rattus norvegicus iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2 iodination and coupling reactions of proteins Sus scrofa iodine + H2O
-
 ?
1.11.1.8 iodide + H2O2 iodination and coupling reactions of proteins Bos taurus iodine + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.8 7
-
 iodide oxidation Bos taurus
1.11.1.8 7.4
-
 guaiacol oxidation Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.8 heme
-
 Rattus norvegicus
1.11.1.8 heme
-
 Sus scrofa
1.11.1.8 heme
-
 Bos taurus