Literature summary extracted from

Colamorea, T.; Di Paola, R.; Macchia, F.; Guerrese, M.C.; Tursi, A.; Butterfield, J.H.; Caiaffa, M.F.; Haeggstrom, J.Z.; Macchia, L.
5-Lipoxygenase Upregulation by Dexamethasone in Human Mast Cells (1999), Biochem. Biophys. Res. Commun., 265, 617-624.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.13.11.34	additional information	Homo sapiens	key enzyme in leukotriene metabolism, in human mast cells glucocorticoids effectively and selectively upregulate the expression	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.13.11.34	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.13.11.34	mast cell	mast cell line HMC-1	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.13.11.34	arachidonate + O2	i.e. 5,8,11,14-eicosatetraenoic acid	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?
1.13.11.34	additional information	key enzyme in leukotriene metabolism, in human mast cells glucocorticoids effectively and selectively upregulate the expression	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)