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Literature summary extracted from

  • Holme, E.; Lindstedt, S.
    Studies on the partial reaction of thymine 7-hydroxylase in the presence of 5-fluorouracil (1982), Biochim. Biophys. Acta, 704, 278-283.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.6 ascorbate
-
 Neurospora crassa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.6 5-fluorouracil linear non-competitive inhibitor Neurospora crassa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.6 Fe2+
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2 Neurospora crassa
-
 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2 Neurospora crassa STA 4
-
 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2 Neurospora crassa
-
 5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2 Neurospora crassa STA 4
-
 5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
1.14.11.6 thymine + 2-oxoglutarate + O2 Neurospora crassa
-
 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?
1.14.11.6 thymine + 2-oxoglutarate + O2 Neurospora crassa STA 4
-
 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.6 Neurospora crassa
-
 STA 4
-
1.14.11.6 Neurospora crassa STA 4
-
 STA 4
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.6 partial Neurospora crassa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.6 1-methylthymine + 2-oxoglutarate + O2
-
 Neurospora crassa 1-methyl-5-(hydroxymethyl)uracil + thymine + formaldehyde + succinate + CO2
-
 ?
1.14.11.6 5-fluorouracil + 2-oxoglutarate + O2
-
 Neurospora crassa ? + succinate + CO2
-
 ?
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2 5-formyluracil reacts subsequently to 5-carboxyuracil Neurospora crassa 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa STA 4 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-formyluracil + 2-oxoglutarate + O2 5-formyluracil reacts subsequently to 5-carboxyuracil Neurospora crassa STA 4 5-carboxyuracil + succinate + CO2
-
 ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa 5-formyluracil + succinate + CO2
-
 ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa 5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa STA 4 5-formyluracil + succinate + CO2
-
 ?
1.14.11.6 5-hydroxymethyluracil + 2-oxoglutarate + O2
-
 Neurospora crassa STA 4 5-formyluracil + succinate + CO2 5-formyluracil reacts subsequently to 5-carboxyuracil ?
1.14.11.6 thymine + 2-oxoglutarate + O2
-
 Neurospora crassa 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?
1.14.11.6 thymine + 2-oxoglutarate + O2
-
 Neurospora crassa STA 4 5-hydroxymethyluracil + succinate + CO2 5-hydroxymethyluracil reacts subsequently to 5-formyluracil ?