EC Number | General Stability | Organism |
---|---|---|
1.14.16.1 | phenylalanine stabilizes | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.1 | 4-chloromercuribenzoate | 1 mM, complete inhibition after 10 min | Homo sapiens | |
1.14.16.1 | 4-Chlorophenylalanine | competitive vs. phenylalanine | Homo sapiens | |
1.14.16.1 | 4-Fluorophenylalanine | above 1 mM | Homo sapiens | |
1.14.16.1 | copper-chelating agents | - |
Homo sapiens | |
1.14.16.1 | diethyldithiocarbamate | 1 mM, 58% inhibition | Homo sapiens | |
1.14.16.1 | DL-alpha-tocopherol | strong inhibition | Homo sapiens | |
1.14.16.1 | Iron-chelating agents | - |
Homo sapiens | |
1.14.16.1 | Thiol-binding reagents | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.16.1 | 0.318 | - |
L-phenylalanine | - |
Homo sapiens | |
1.14.16.1 | 1 | - |
4-Fluorophenylalanine | approx. value | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.14.16.1 | 54000 | - |
2 * 54000, fetal liver enzyme, SDS-PAGE | Homo sapiens |
1.14.16.1 | 110000 | - |
fetal liver enzyme, gel filtration | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.16.1 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.16.1 | fetal, newborn and adult enzyme are probably identical | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.16.1 | liver | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.16.1 | 0.225 | - |
liver enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.16.1 | 4-fluorophenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | ? | - |
? | |
1.14.16.1 | L-phenylalanine + tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + dihydrobiopterin + H2O | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.16.1 | dimer | 2 * 54000, fetal liver enzyme, SDS-PAGE | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.1 | tetrahydrobiopterin | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.16.1 | 1.1 | - |
4-Chlorophenylalanine | - |
Homo sapiens |