EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.16.2 | isoform 1 hTH1 and His-tagged truncated mutant, expression in Escherichia coli | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.14.16.2 | crystal structure, analysis of tetrahydropterin analogues binding to isoform hTH1 | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.16.2 | additional information | truncated hTH1 isoform lacking the 150 N-terminal amino acids | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.2 | 2,4-diamino-6-dihydroxypropyl-5,6,7,8-tetrahydropterin | competitive against (6R)-L-erythro-tetrahydrobiopterin | Homo sapiens | |
1.14.16.2 | 5(N-phenylthiocarbamoyl)-5,6,7,8-tetrahydropterin | - |
Homo sapiens | |
1.14.16.2 | 5-methyl-5,6,7,8-tetrahydropterin | competitive against (6R)-L-erythro-tetrahydrobiopterin | Homo sapiens | |
1.14.16.2 | 6-[2-(4-benzoylphenyl)propionyloxymethyl]-5,6,7,8-tetrahydropterin | competitive against (6R)-L-erythro-tetrahydrobiopterin | Homo sapiens | |
1.14.16.2 | 7-amino-3,3a,4,5-tetrahydro-8H-2-oxa-5,6,8,9b-tetraaza-cyclopenta[a]naphthalene-1,9-dione | competitive against (6R)-L-erythro-tetrahydrobiopterin | Homo sapiens | |
1.14.16.2 | 8-methyl-6,7-dimethyl-5,6,7,8-tetrahydropterin | competitive against (6R)-L-erythro-tetrahydrobiopterin | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.16.2 | additional information | - |
additional information | Km-values of diverse tetrahydropterin analogues, substituted at C6, C7 or C3 | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.16.2 | Iron | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.16.2 | Homo sapiens | - |
isoform 1 hTH1 | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.14.16.2 | L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | ligand binding model, hTH1 | Homo sapiens |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.14.16.2 | 1 | - |
about, purified recombinant enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.16.2 | L-tyrosine + (6R)-L-erythro-tetrahydrobiopterin + O2 | recombinant hTH1 | Homo sapiens | ? | - |
? | |
1.14.16.2 | L-tyrosine + 2-methyl-4-oxo-5,6,7,8-tetrahydropterin + O2 | recombinant hTH1 | Homo sapiens | ? | - |
? | |
1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 | recombinant hTH1 | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
1.14.16.2 | additional information | active with diverse tetrahydropterin analogues, substituted at C6, C7 or C3, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.16.2 | TH | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.16.2 | 25 | - |
recombinant hTH1, assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.16.2 | 7 | - |
recombinant hTH1, assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.16.2 | 0.001 | - |
6-[2-(4-benzoylphenyl)propionyloxymethyl]-5,6,7,8-tetrahydropterin | - |
Homo sapiens | |
1.14.16.2 | 0.016 | - |
2,4-diamino-6-dihydroxypropyl-5,6,7,8-tetrahydropterin | - |
Homo sapiens | |
1.14.16.2 | 0.063 | - |
5-methyl-5,6,7,8-tetrahydropterin | - |
Homo sapiens | |
1.14.16.2 | 0.138 | - |
7-amino-3,3a,4,5-tetrahydro-8H-2-oxa-5,6,8,9b-tetraaza-cyclopenta[a]naphthalene-1,9-dione | - |
Homo sapiens | |
1.14.16.2 | 0.617 | - |
8-methyl-6,7-dimethyl-5,6,7,8-tetrahydropterin | - |
Homo sapiens | |
1.14.16.2 | 2.83 | - |
5(N-phenylthiocarbamoyl)-5,6,7,8-tetrahydropterin | - |
Homo sapiens |