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Literature summary extracted from

  • Martinez, A.; Haavik, J.; Flatmark, T.; Arrondo, J.L.; Muga, A.
    Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation (1996), J. Biol. Chem., 271, 19737-19742.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.16.2 additional information activation by phosphorylation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 Catecholamines feedback inhibition, reversible by phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 Homo sapiens rate-limiting step in catecholamine biosynthesis 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Homo sapiens
-
 isoform 1 hTH1
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.16.2 L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine secondary structure and conformation analysis of phosphorylated and unphosphorylated isoform hTH1 Homo sapiens
a
1.14.16.2 L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine phosphorylation site of hTH1 is Ser-40 Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 rate-limiting step in catecholamine biosynthesis Homo sapiens 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 TH
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.16.2 additional information
-
 thermal stability of hTH1 is increased by phosphorylation at Ser-40 Homo sapiens