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Literature summary extracted from

  • Hamdan, F.F.; Ribeiro, P.
    Cloning and characterization of a novel form of tyrosine hydroxylase from the human parasite, Schistosoma mansoni (1998), J. Neurochem., 71, 1369-1380.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.16.2 expression as His-tagged protein in Escherichia coli, amino acid sequence analysis Schistosoma mansoni

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.2 Catecholamines
-
 Schistosoma mansoni
1.14.16.2 tyrosine at concentrations above 0.03 mM Schistosoma mansoni

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.2 0.0095
-
 tyrosine
-
 Schistosoma mansoni
1.14.16.2 0.045
-
 tetrahydrobiopterin
-
 Schistosoma mansoni

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.2 Schistosoma mansoni
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.16.2 recombinant from Escherichia coli Schistosoma mansoni

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.16.2 0.00003
-
 crude extract Schistosoma mansoni
1.14.16.2 0.78
-
 purified enzyme Schistosoma mansoni

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2 tetrahydropterin absolutely required Schistosoma mansoni 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?
1.14.16.2 L-tyrosine + tetrahydrobiopterin + O2
-
 Schistosoma mansoni L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.14.16.2 TH
-
 Schistosoma mansoni