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Literature summary extracted from
- Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase (1998), J. Neurosci. Res., 54, 691-697.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | dopamine quinone | covalent modification and inactivation | Rattus norvegicus |  |
| 1.14.16.2 | L-Dopa | modest feedback inhibition | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.16.2 | cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 | Rattus norvegicus | rate-limiting step in catecholamine biosynthesis | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | Rattus norvegicus | - |
PC12 cells | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | PC-12 cell | - |
Rattus norvegicus | - |
| 1.14.16.2 | pheochromocytoma cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | L-tyrosine + 6-methyltetrahydropterin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
| 1.14.16.2 | L-tyrosine + tetrahydrobiopterin + O2 | rate-limiting step in catecholamine biosynthesis | Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.2 | TH | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.2 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.2 | 6 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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