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Literature summary extracted from

  • Joh, T.H.; Shikimi, T.; Pickel, V.M.; Reis, D.J.
    Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain (1975), Proc. Natl. Acad. Sci. USA, 72, 3575-3579.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.4 cytoplasm cell body Rattus norvegicus 5737
-
1.14.16.4 endoplasmic reticulum associated with cell body Rattus norvegicus 5783
-
1.14.16.4 Golgi apparatus associated with cell body Rattus norvegicus 5794
-
1.14.16.4 microtubule dendrites and axons Rattus norvegicus 5874
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 Rattus norvegicus enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.16.4
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.4 brain region of the raphe nucleus of rat midbrain Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.16.4 0.045
-
 brain tryptophan hydroxylase Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + tetrahydropteridine + O2
-
 Rattus norvegicus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?
1.14.16.4 L-tryptophan + tetrahydropteridine + O2 enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin Rattus norvegicus 5-hydroxy-L-tryptophan + dihydropteridine + H2O
-
 ?