BRENDA - Enzyme Database show

Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series

Rodriguez, A.; Sarda, P.; Boulot, P.; Leger, C.L.; Descomps, B.; Lipids 34, 23-30 (1999)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.19.3
N-ethylmaleimide
n-3 DELTA6-desaturase is not inhibited, it increases, NEM specifically inhibits DELTA6-desaturase activity in the n-6 series, but not in the n-3-series
Homo sapiens
1.14.19.3
N-ethylmaleimide
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.19.3
endoplasmic reticulum
-
Homo sapiens
5783
-
1.14.19.3
microsome
membrane
Homo sapiens
-
-
1.14.19.3
microsome
membrane
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
Rattus norvegicus
-
gamma-linolenic acid + A + H2O
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
Homo sapiens
key enzyme localized in the endoplasmic reticulum
gamma-linolenic acid + A + H2O
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.19.3
Homo sapiens
-
human
-
1.14.19.3
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.19.3
fetus
-
Homo sapiens
-
1.14.19.3
fetus
-
Rattus norvegicus
-
1.14.19.3
liver
fetal liver
Homo sapiens
-
1.14.19.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.19.3
alpha-linolenic acid + AH2 + O2
-
438418
Homo sapiens
stearidonic acid + A + H2O
-
438418
Homo sapiens
?
1.14.19.3
alpha-linolenic acid + AH2 + O2
-
438418
Rattus norvegicus
stearidonic acid + A + H2O
-
438418
Rattus norvegicus
?
1.14.19.3
linoleic acid + AH2 + O2
-
438418
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
key enzyme localized in the endoplasmic reticulum
438418
Homo sapiens
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438418
Homo sapiens
gamma-linolenic acid + A + H2O
-
438418
Homo sapiens
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438418
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
438418
Rattus norvegicus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.19.3
N-ethylmaleimide
n-3 DELTA6-desaturase is not inhibited, it increases, NEM specifically inhibits DELTA6-desaturase activity in the n-6 series, but not in the n-3-series
Homo sapiens
1.14.19.3
N-ethylmaleimide
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.19.3
endoplasmic reticulum
-
Homo sapiens
5783
-
1.14.19.3
microsome
membrane
Homo sapiens
-
-
1.14.19.3
microsome
membrane
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.19.3
linoleic acid + AH2 + O2
Rattus norvegicus
-
gamma-linolenic acid + A + H2O
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
Homo sapiens
key enzyme localized in the endoplasmic reticulum
gamma-linolenic acid + A + H2O
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.19.3
fetus
-
Homo sapiens
-
1.14.19.3
fetus
-
Rattus norvegicus
-
1.14.19.3
liver
fetal liver
Homo sapiens
-
1.14.19.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.19.3
alpha-linolenic acid + AH2 + O2
-
438418
Homo sapiens
stearidonic acid + A + H2O
-
438418
Homo sapiens
?
1.14.19.3
alpha-linolenic acid + AH2 + O2
-
438418
Rattus norvegicus
stearidonic acid + A + H2O
-
438418
Rattus norvegicus
?
1.14.19.3
linoleic acid + AH2 + O2
-
438418
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
linoleic acid + AH2 + O2
key enzyme localized in the endoplasmic reticulum
438418
Homo sapiens
gamma-linolenic acid + A + H2O
-
-
-
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438418
Homo sapiens
gamma-linolenic acid + A + H2O
-
438418
Homo sapiens
?
1.14.19.3
octadeca-9,12-dienoic acid + AH2 + O2
-
438418
Rattus norvegicus
gamma-linolenic acid + A + H2O
-
438418
Rattus norvegicus
?