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Literature summary extracted from
- Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17,dione hydroxylase activities by derivatives of 5alpha- and 5beta-androstane (1999), J. Steroid Biochem., 35, 465-471.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.12 | 5alpha-androstane-17beta-ol | exhibits an IC50 of 0.046 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.026 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.047 against androstendione 16beta-hydroxylase activity | Rattus norvegicus |  |
| 1.14.99.12 | 5alpha-androstane-3beta-ol | exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | 5alpha-androstane-3beta-ol-17-one | exhibits an IC50 of 0.12 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.14 against androstendione 16beta-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | 5beta-androstane-17beta-ol | exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.065 against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | 5beta-androstane-3-one-17-one | exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | 5beta-androstane-3beta-ol | exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | 5beta-androstane-3beta-ol-17-one | exhibits an IC50 of 0.047 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.06 mM against androstendione 7alpha-hydroxylase activity and an IC50 of 0.051 against androstendione 16alpha-hydroxylase activity and an IC50 of 0.087 against androstendione 16beta-hydroxylase activity; exhibits an IC50 of 0.095 against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | |
| 1.14.99.12 | additional information | 5beta-reduced steroids are more potent inhibitors than 5alpha-reduced epimers | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.12 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.12 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.12 | liver | - |
Rattus norvegicus | - |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.99.12 | 0.007 | - |
exhibits an IC50 of 0.027 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.007 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3beta-ol | |
| 1.14.99.12 | 0.026 | - |
IC50 of 0.026 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 1.14.99.12 | 0.046 | - |
exhibits an IC50 of 0.046 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 1.14.99.12 | 0.047 | - |
IC50 of 0.047 mM against androstendione 16beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-17beta-ol | |
| 1.14.99.12 | 0.065 | - |
IC50 of 0.065 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-17beta-ol | |
| 1.14.99.12 | 0.071 | - |
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity and an IC50 of 0.071 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol | |
| 1.14.99.12 | 0.084 | - |
exhibits an IC50 of 0.084 mM against androstendione 7alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3-one-17-one | |
| 1.14.99.12 | 0.095 | - |
exhibits an IC50 of 0.095 mM against androstendione 16alpha-hydroxylase activity | Rattus norvegicus | 5beta-androstane-3beta-ol-17-one | |
| 1.14.99.12 | 0.11 | - |
exhibits an IC50 of 0.11 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5beta-androstane-17beta-ol | |
| 1.14.99.12 | 0.12 | - |
exhibits an IC50 of 0.12 mM against androstendione 6beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol-17-one | |
| 1.14.99.12 | 0.14 | - |
IC50 of 0.14 mM against androstendione 16beta-hydroxylase activity | Rattus norvegicus | 5alpha-androstane-3beta-ol-17-one | |
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