BRENDA - Enzyme Database show

Regulation of the NADH and NADPH-ferredoxin oxidoreductases in clostridia of the butyric group

Petitdemange, H.; Cherrier, C.; Raval, G.; Gay, R.; Biochim. Biophys. Acta 421, 334-347 (1976)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.18.1.3
acetyl Co-A
obligate activator
Clostridium acetobutylicum
1.18.1.3
acetyl Co-A
obligate activator
Clostridium pasteurianum
1.18.1.3
acetyl Co-A
obligate activator
Clostridium tyrobutyricum
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity
Clostridium acetobutylicum
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity
Clostridium pasteurianum
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity; in cells growing on pyruvate/acetate NADH does not control enzyme activity
Clostridium tyrobutyricum
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.18.1.3
additional information
Clostridium pasteurianum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
1.18.1.3
additional information
Clostridium acetobutylicum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
1.18.1.3
additional information
Clostridium tyrobutyricum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.18.1.3
Clostridium acetobutylicum
-
-
-
1.18.1.3
Clostridium pasteurianum
-
-
-
1.18.1.3
Clostridium tyrobutyricum
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium pasteurianum
?
-
-
-
-
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium acetobutylicum
?
-
-
-
-
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium tyrobutyricum
?
-
-
-
-
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium pasteurianum
reduced ferredoxin + NAD+
-
-
-
r
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium acetobutylicum
reduced ferredoxin + NAD+
-
-
-
r
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium tyrobutyricum
reduced ferredoxin + NAD+
-
-
-
r
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.18.1.3
NADH
-
Clostridium acetobutylicum
1.18.1.3
NADH
-
Clostridium tyrobutyricum
1.18.1.3
NADH
-
Clostridium pasteurianum
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.18.1.3
acetyl Co-A
obligate activator
Clostridium acetobutylicum
1.18.1.3
acetyl Co-A
obligate activator
Clostridium pasteurianum
1.18.1.3
acetyl Co-A
obligate activator
Clostridium tyrobutyricum
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.18.1.3
NADH
-
Clostridium acetobutylicum
1.18.1.3
NADH
-
Clostridium tyrobutyricum
1.18.1.3
NADH
-
Clostridium pasteurianum
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity
Clostridium acetobutylicum
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity
Clostridium pasteurianum
1.18.1.3
NADH
competitive inhibitor of ferredoxin-NAD+ reductase activity; in cells growing on pyruvate/acetate NADH does not control enzyme activity
Clostridium tyrobutyricum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.18.1.3
additional information
Clostridium pasteurianum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
1.18.1.3
additional information
Clostridium acetobutylicum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
1.18.1.3
additional information
Clostridium tyrobutyricum
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium pasteurianum
?
-
-
-
-
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium acetobutylicum
?
-
-
-
-
1.18.1.3
additional information
the enzyme can, depending on cellular conditions, produce or oxidize NADH. NADH-ferredoxin reductase can control the level of NAD+ and NADH in the cell
437850
Clostridium tyrobutyricum
?
-
-
-
-
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium pasteurianum
reduced ferredoxin + NAD+
-
-
-
r
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium acetobutylicum
reduced ferredoxin + NAD+
-
-
-
r
1.18.1.3
oxidized ferredoxin + NADH
-
437850
Clostridium tyrobutyricum
reduced ferredoxin + NAD+
-
-
-
r