Any feedback?
Literature summary extracted from
- Kinetics of membrane-bound aldehyde dehydrogenase from Acinetobacter calcoaceticus (1987), Biol. Chem. Hoppe-Seyler, 368, 101-109.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.4 | butyric acid ethyl ester | - |
Acinetobacter calcoaceticus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.4 | 1,10-phenanthroline | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | BO33- | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Butanal | substrate inhibition | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Chloralhydrate | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | CN- | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Cu2+ | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | decanal | substrate inhibition | Acinetobacter calcoaceticus | |
| 1.2.1.4 | diisopropylfluorophosphate | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | EDTA | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Fe2+ | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | hexanal | substrate inhibition | Acinetobacter calcoaceticus | |
| 1.2.1.4 | mercaptoethanol | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | NADPH | product inhibition | Acinetobacter calcoaceticus | |
| 1.2.1.4 | octanal | substrate inhibition | Acinetobacter calcoaceticus | |
| 1.2.1.4 | PCMB | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Phenylmethylsulfonylfluoride | non-competitive | Acinetobacter calcoaceticus | |
| 1.2.1.4 | Sn2+ | non-competitive | Acinetobacter calcoaceticus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.4 | 0.0015 | - |
decanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.0039 | - |
Nonanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.0093 | - |
octanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.055 | - |
Heptanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.056 | - |
NADP+ | reaction with heptanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.064 | - |
NADP+ | reaction with nonanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.077 | - |
NADP+ | reaction with pentanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.087 | - |
NADP+ | reaction with octanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.1 | - |
NADP+ | reaction with decanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.14 | - |
NADP+ | reaction with butanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.21 | - |
NADP+ | reaction with hexanal | Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.46 | - |
hexanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.92 | - |
pentanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 1.6 | - |
Butanal | - |
Acinetobacter calcoaceticus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.2.1.4 | membrane | - |
Acinetobacter calcoaceticus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.4 | additional information | Acinetobacter calcoaceticus | inducible enzyme | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.4 | Acinetobacter calcoaceticus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.4 | butanal + NADP+ + H2O | - |
Acinetobacter calcoaceticus | butyrate + NADPH + H+ | - |
? | |
| 1.2.1.4 | decanal + NADP+ | - |
Acinetobacter calcoaceticus | decanoate + NADPH | - |
? | |
| 1.2.1.4 | heptanal + NADP+ | - |
Acinetobacter calcoaceticus | heptanoate + NADPH | - |
? | |
| 1.2.1.4 | hexanal + NADP+ | - |
Acinetobacter calcoaceticus | hexanoate + NADPH | - |
? | |
| 1.2.1.4 | additional information | inducible enzyme | Acinetobacter calcoaceticus | ? | - |
? | |
| 1.2.1.4 | nonanal + NAD+ + H2O | - |
Acinetobacter calcoaceticus | nonanoate + NADH + H+ | - |
r | |
| 1.2.1.4 | octanal + NADP+ + H2O | - |
Acinetobacter calcoaceticus | octanoate + NADPH + H+ | - |
? | |
| 1.2.1.4 | pentanal + NADP+ | - |
Acinetobacter calcoaceticus | pentanoate + NADPH | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.4 | 9 | 10.5 | - |
Acinetobacter calcoaceticus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.4 | 8 | 11.5 | pH 8.5: about 60% of maximal activity, pH 11.5: about 80% of maximal activity | Acinetobacter calcoaceticus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.4 | NADP+ | reaction with NAD+ is less than 1% of the activity with NADP+ | Acinetobacter calcoaceticus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.2.1.4 | 0.0000000014 | - |
PCMB | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.0055 | - |
1,10-phenanthroline | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.0095 | - |
Chloralhydrate | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.027 | - |
EDTA | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.035 | - |
decanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.1 | - |
octanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 0.22 | - |
NADPH | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 1 | - |
hexanal | - |
Acinetobacter calcoaceticus | |
| 1.2.1.4 | 7.5 | - |
Butanal | - |
Acinetobacter calcoaceticus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
