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Literature summary extracted from

  • Alvear, M.; Jabalquinto, A.M.; Eyzaguirre, J.; Cardemil, E.
    Purification and characterization of avian liver mevalonate-5-pyrophosphate decarboxylase (1982), Biochemistry, 21, 4646-4650.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.33 additional information no requirement for SH-containing reagents for activity Gallus gallus

General Stability

EC Number General Stability Organism
4.1.1.33 no requirement for SH-containing reagents for stability Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.33 citrate inhibits below pH 4.8 Gallus gallus
4.1.1.33 phosphate
-
 Gallus gallus
4.1.1.33 Phthalate
-
 Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.33 0.0141
-
 5-diphosphomevalonate
-
 Gallus gallus
4.1.1.33 0.504
-
 ATP
-
 Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.33 Mg2+ divalent cation required, Mg2+ is most effective, maximal activity at 1 mM Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.33 43500
-
 2 * 43500, SDS-PAGE Gallus gallus
4.1.1.33 81500
-
 sucrose density gradient centrifugation Gallus gallus
4.1.1.33 87600
-
 gel filtration Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.33 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.33
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.33 liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.33 6.26
-
-
 Gallus gallus

Storage Stability

EC Number Storage Stability Organism
4.1.1.33 -20°C, Tris-HCl buffer, pH 7.0, 20% glycerol, 75 mM KCl, stable for 1 month Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.33 ATP + 5-diphosphomevalonate high specificity for ATP Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.33 dimer 2 * 43500, SDS-PAGE Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.33 4 6.5
-
 Gallus gallus