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Literature summary extracted from

  • Phillips, M.A.; Coffino, P.; Wang, C.C.
    Trypanosoma brucei ornithine decarboxylase: enzyme purification, characterization, and expression in Escherichia coli (1988), J. Biol. Chem., 263, 17933-17941.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.17 expression in Escherichia coli Trypanosoma brucei

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.17 alpha-DL-difluoromethylornithine irreversibel Trypanosoma brucei
4.1.1.17 additional information the enzyme is an important target for antitrypanosomal chemotherapy Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.17 0.28
-
 L-Orn native enzyme Trypanosoma brucei
4.1.1.17 0.33
-
 L-Orn recombinant enzyme Trypanosoma brucei

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.17 45000
-
 2 * 45000, SDS-PAGE Trypanosoma brucei
4.1.1.17 90000
-
 native enzyme, gel filtration Trypanosoma brucei
4.1.1.17 92000
-
 recombinant enzyme, gel filtration Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.17 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.17
-
 Trypanosoma brucei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.17 trypomastigote
-
 Trypanosoma brucei
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.17 additional information
-
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.17 L-Orn
-
 Trypanosoma brucei Putrescine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.17 dimer 2 * 45000, SDS-PAGE Trypanosoma brucei