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Literature summary extracted from

  • Schmidt, H.; Bode, R.; Birnbaum, D.
    Regulation of the lysine biosynthesis in Pichia guilliermondii (1989), Antonie van Leeuwenhoek, 56, 337-347.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.7 adenosine slight Meyerozyma guilliermondii
1.5.1.7 ADP
-
 Meyerozyma guilliermondii
1.5.1.7 AMP
-
 Meyerozyma guilliermondii
1.5.1.7 ATP
-
 Meyerozyma guilliermondii
1.5.1.10 L-leucine
-
 Meyerozyma guilliermondii
1.5.1.10 L-tryptophan
-
 Meyerozyma guilliermondii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.7 0.13
-
 NADH
-
 Meyerozyma guilliermondii
1.5.1.7 0.5
-
 2-oxoglutarate
-
 Meyerozyma guilliermondii
1.5.1.7 0.9
-
 L-lysine
-
 Meyerozyma guilliermondii
1.5.1.10 0.17
-
 NADP+
-
 Meyerozyma guilliermondii
1.5.1.10 1.25
-
 saccharopine
-
 Meyerozyma guilliermondii

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.1.7 45000
-
 gel filtration with Sephadex G-200 Meyerozyma guilliermondii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii involved in lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii H17 involved in lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Meyerozyma guilliermondii H17 last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH Meyerozyma guilliermondii lysine biosynthesis N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH Meyerozyma guilliermondii H17 lysine biosynthesis N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.7 Meyerozyma guilliermondii
-
 yeast
-
1.5.1.7 Meyerozyma guilliermondii H17
-
 yeast
-
1.5.1.10 Meyerozyma guilliermondii
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.7 0.00018
-
-
 Meyerozyma guilliermondii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine biosynthesis Meyerozyma guilliermondii L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Meyerozyma guilliermondii L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine biosynthesis Meyerozyma guilliermondii H17 L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Meyerozyma guilliermondii H17 L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH lysine biosynthesis Meyerozyma guilliermondii N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH lysine biosynthesis Meyerozyma guilliermondii H17 N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.7 7.1
-
 saccharopine + NAD+ + H2O Meyerozyma guilliermondii
1.5.1.10 8.8
-
 saccharopine degradation Meyerozyma guilliermondii

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.7 NAD+
-
 Meyerozyma guilliermondii