Literature summary extracted from

Schlossberg, M.A.; Richert, D.A.; Bloom, R.J.; Westerfeld, W.W.
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate:glyoxylate carboligase (1968), Biochemistry, 7, 333-337.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.2.1.5	Bos taurus	-	bovine	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.2.1.5	heart	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.2.1.5	2-oxoglutarate + glyoxylate	-	Bos taurus	2-hydroxy-3-oxohexandioate + CO2	i. e. 2-hydroxy-3-oxoadipic acid	?
2.2.1.5	2-oxoglutarate + glyoxylate	-	Bos taurus	2-hydroxy-3-oxohexandioate + CO2	further decarboxylation leads to 5-hydroxy-4-ketovaleric acid	?

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.2.1.5	37	-	enzyme assay at	Bos taurus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.2.1.5	7.1	-	enzyme assay at	Bos taurus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.2.1.5	thiamine diphosphate	-	Bos taurus

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Release 2023.1 (January 2023)