Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tate, S.S.; Meister, A.
    L-Aspartate-beta-decarboxylase. Structure, catalytic activities, and allosteric regulation (1971), Adv. Enzymol. Relat. Areas Mol. Biol., 35, 503-543.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.12 2-Oxo-5-carbamidopentanoate activates Alcaligenes faecalis
4.1.1.12 2-oxo-5-guanidinopentanoate activates Alcaligenes faecalis
4.1.1.12 2-oxoglutarate activates Alcaligenes faecalis
4.1.1.12 2-oxoglutarate activates Achromobacter sp.
4.1.1.12 2-oxoglutarate activates Pseudomonas dacunhae
4.1.1.12 2-Oxoisohexanoate activates Alcaligenes faecalis
4.1.1.12 2-oxoisopentanoate activates Alcaligenes faecalis
4.1.1.12 2-Oxomalonate activates Alcaligenes faecalis
4.1.1.12 2-oxophenylacetate activates Alcaligenes faecalis
4.1.1.12 beta-cyano-L-Ala competitive towards L-Asp Alcaligenes faecalis
4.1.1.12 D-2-Oxo-3-methylpentanoate activates Alcaligenes faecalis
4.1.1.12 glyoxylate activates Alcaligenes faecalis
4.1.1.12 glyoxylate activates Achromobacter sp.
4.1.1.12 L-2-Oxo-3-methylpentanoate activates Alcaligenes faecalis
4.1.1.12 additional information interacts with a number of vitamin B6 5'-phosphate analogues Alcaligenes faecalis
4.1.1.12 phenylpyruvate activates Alcaligenes faecalis
4.1.1.12 pyruvate activates Alcaligenes faecalis
4.1.1.12 pyruvate activates Achromobacter sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.12 0.024
-
erythro-beta-hydroxyaspartate
-
Alcaligenes faecalis
4.1.1.12 0.063
-
beta-chloro-L-Ala
-
Alcaligenes faecalis
4.1.1.12 0.089
-
threo-beta-hydroxyaspartate
-
Alcaligenes faecalis
4.1.1.12 0.68
-
L-Asp
-
Alcaligenes faecalis
4.1.1.12 3
-
aminomalonate
-
Alcaligenes faecalis
4.1.1.12 4.8
-
L-cysteinesulfinate
-
Alcaligenes faecalis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.12 Acetobacter sp.
-
-
-
4.1.1.12 Achromobacter sp.
-
-
-
4.1.1.12 Alcaligenes faecalis
-
-
-
4.1.1.12 Astacoidea
-
-
-
4.1.1.12 Bombyx mori
-
-
-
4.1.1.12 Clostridium perfringens
-
-
-
4.1.1.12 Desulfovibrio desulfuricans
-
-
-
4.1.1.12 Lobster
-
-
-
4.1.1.12 Nocardia globerula
-
-
-
4.1.1.12 Pseudomonas dacunhae
-
-
-
4.1.1.12 Pseudomycobacteria
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.12 Aminomalonate
-
Alcaligenes faecalis Gly + CO2
-
?
4.1.1.12 beta-chloro-L-Ala + H2O
-
Alcaligenes faecalis pyruvate + Cl- + NH4+
-
?
4.1.1.12 erythro-beta-Hydroxyaspartate
-
Alcaligenes faecalis L-Ser + CO2
-
?
4.1.1.12 L-Asp
-
Alcaligenes faecalis L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Bombyx mori L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Achromobacter sp. L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Nocardia globerula L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Pseudomonas dacunhae L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Pseudomycobacteria L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Clostridium perfringens L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Desulfovibrio desulfuricans L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Acetobacter sp. L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Astacoidea L-Ala + CO2
-
?
4.1.1.12 L-Asp
-
Lobster L-Ala + CO2
-
?
4.1.1.12 L-Cysteinesulfinate
-
Alcaligenes faecalis L-Ala + SO2
-
?
4.1.1.12 L-Cysteinesulfinate
-
Pseudomonas dacunhae L-Ala + SO2
-
?
4.1.1.12 additional information
-
Pseudomonas dacunhae ?
-
?
4.1.1.12 additional information transamination between L-Asp and pyruvate Alcaligenes faecalis ?
-
?
4.1.1.12 threo-beta-Hydroxyaspartate
-
Alcaligenes faecalis L-Ser + CO2
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.12 pyridoxal 5'-phosphate
-
Alcaligenes faecalis
4.1.1.12 pyridoxal 5'-phosphate
-
Achromobacter sp.
4.1.1.12 pyridoxal 5'-phosphate activates Pseudomonas dacunhae
4.1.1.12 pyridoxal 5'-phosphate activates Clostridium perfringens