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Literature summary extracted from

  • Dick, R.; Murray, B.P.; Reid, M.J.; Correia, M.A.
    Structure-Function Relationships of Rat Hepatic Tryptophan 2,3-Dioxygenase: Identification of the Putative Heme-Ligating Histidine Residues (2001), Arch. Biochem. Biophys., 392, 71-78.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.52 H238A mutant retains little or no heme, strong reduction of activity Rattus norvegicus
1.13.11.52 H75A mutant retains little or no heme, strong reduction of activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.52 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-Trp + O2 Rattus norvegicus enzyme controls the physiological flux of Trp into both the serotonergic and kynureninic pathways L-formylkynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 L-Trp + O2
-
 Rattus norvegicus L-formylkynurenine
-
 ?
1.13.11.52 L-Trp + O2 enzyme controls the physiological flux of Trp into both the serotonergic and kynureninic pathways Rattus norvegicus L-formylkynurenine
-
 ?