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Literature summary extracted from

  • Hitchcock, M.J.M.; Katz, E.
    Purification and characterization of tryptophan dioxygenase from Streptomyces parvulus (1988), Arch. Biochem. Biophys., 261, 148-160.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 3-hydroxyanthranilic acid
-
 Streptomyces parvulus
1.13.11.52 actinomycin D
-
 Streptomyces parvulus
1.13.11.52 Cinnabarinic acid
-
 Streptomyces parvulus
1.13.11.52 CN- 5 mM, 98% inhibition Streptomyces parvulus
1.13.11.52 D-Trp
-
 Streptomyces parvulus
1.13.11.52 DL-5-fluorotryptophan
-
 Streptomyces parvulus
1.13.11.52 DL-5-Methyltryptophan
-
 Streptomyces parvulus
1.13.11.52 DL-alpha-methyltryptophan
-
 Streptomyces parvulus
1.13.11.52 N3- 5 mM, 5% inhibition Streptomyces parvulus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.3
-
 L-Trp
-
 Streptomyces parvulus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Streptomyces parvulus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Streptomyces parvulus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-Trp + O2 0.7% of the activity with L-Trp Streptomyces parvulus N-formyl-D-kynurenine
-
 ?
1.13.11.52 DL-5-fluoro-methyltryptophan + O2 30.6% of the activity with L-Trp Streptomyces parvulus ?
-
 ?
1.13.11.52 DL-5-methyltryptophan + O2 15.1% of the activity with L-Trp Streptomyces parvulus ?
-
 ?
1.13.11.52 DL-alpha-methyltryptophan + O2 9.0% of the activity with L-Trp Streptomyces parvulus alpha-methyl-N-formyl-DL-kynurenine
-
 ?
1.13.11.52 L-Trp + O2
-
 Streptomyces parvulus L-formylkynurenine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.52 8
-
-
 Streptomyces parvulus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.13.11.52 6 9 pH 6.0: about 45% of maximal activity, pH 9.0: about 40% of maximal activity Streptomyces parvulus

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme the prosthetic group is tightly bound to the enzyme Streptomyces parvulus