BRENDA - Enzyme Database

Interaction of glutathione-insulin transhydrogenase (disulfide interchange enzyme) with phospholipids

Varandani, P.T.; Nafz, M.A.; Biochim. Biophys. Acta 438, 358-369 (1976)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
Phospholipids
slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine
Bos taurus
1.8.4.2
Phospholipids
slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
lysophosphatidylcholine
-
Bos taurus
1.8.4.2
lysophosphatidylcholine
-
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.4.2
microsome
-
Rattus norvegicus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.4.2
Bos taurus
-
-
-
1.8.4.2
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.8.4.2
-
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394847
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394847
Rattus norvegicus
GSSG + protein-dithiol
-
394847
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394847
Bos taurus
GSSG + protein-dithiol
-
394847
Bos taurus
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
Phospholipids
slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine
Bos taurus
1.8.4.2
Phospholipids
slight activation by all phospholipids tested except for phosphatidic acid and phosphatidylserine, highest activation by phosphatidylethanolamine
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.4.2
lysophosphatidylcholine
-
Bos taurus
1.8.4.2
lysophosphatidylcholine
-
Rattus norvegicus
1.8.4.2
phosphatidic acid
-
Bos taurus
1.8.4.2
phosphatidic acid
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.4.2
microsome
-
Rattus norvegicus
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.4.2
-
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394847
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394847
Rattus norvegicus
GSSG + protein-dithiol
-
394847
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394847
Bos taurus
GSSG + protein-dithiol
-
394847
Bos taurus
?