Literature summary extracted from

Fournet, A.; Inchausti, A.; Yaluff, G.; Royas De Arias, A.; Guinaudeau, H.; Bruneton, J.; Breidenbach, M.A.; Karplus, P.A.; Faerman, C.H.
Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase (1998), J. Enzyme Inhib., 13, 1-9.

Application

EC Number	Application	Comment	Organism
1.8.1.12	medicine	target enzyme for chemotherapy against Chagas' disease	Trypanosoma cruzi

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.12	bisbenzylisoquinoline alkaloids	e.g. cepharanthine, (-)curine, daphnoline, antioquine, limacine, cycleanine	Trypanosoma cruzi
1.8.1.12	cepharanthine	-	Trypanosoma cruzi
1.8.1.12	cycleanine	-	Trypanosoma cruzi

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.8.1.12	0.05	-	trypanothione disulfide	with cepharanthine	Trypanosoma cruzi
1.8.1.12	0.099	-	trypanothione disulfide	with cycleanine	Trypanosoma cruzi

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.12	Trypanosoma cruzi	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.1.12	trypanothione disulfide + NADPH	-	Trypanosoma cruzi	trypanothione + NADP+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.12	FAD	-	Trypanosoma cruzi
1.8.1.12	NADPH	-	Trypanosoma cruzi

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.8.1.12	0.0076	-	cepharanthine	-	Trypanosoma cruzi
1.8.1.12	0.194	-	cycleanine	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)