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Literature summary extracted from

  • Ramsay, R.R.; Singer, T.P.
    The kinetic mechanisms of monoamine oxidases A and B (1991), Biochem. Soc. Trans., 19, 219-223.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 amphetamine
-
 Bos taurus
1.4.3.4 amphetamine
-
 Homo sapiens
1.4.3.4 D-amphetamine
-
 Bos taurus
1.4.3.4 D-amphetamine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 0.04
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
 Bos taurus
1.4.3.4 0.04
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MAO-A Homo sapiens
1.4.3.4 0.11
-
 kynuramine MAO-A Homo sapiens
1.4.3.4 0.19 0.25 Phenylethylamine MAO-B Bos taurus
1.4.3.4 0.48 0.51 benzylamine MAO-B Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus
-
-
-
1.4.3.4 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.4.3.4 RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 mechanism of monoamine oxidase A and B Homo sapiens
a
1.4.3.4 RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 mechanism of monoamine oxidase A and B Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Homo sapiens
-
1.4.3.4 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.4 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + H2O + O2
-
 Bos taurus ?
-
 ?
1.4.3.4 2-phenylethylamine + H2O + O2
-
 Homo sapiens 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 2-phenylethylamine + H2O + O2
-
 Bos taurus 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.4 benzylamine + H2O + O2
-
 Bos taurus benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2
-
 Bos taurus 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2
-
 Homo sapiens RCHO + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2
-
 Bos taurus RCHO + NH3 + H2O2
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 0.16
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MAO-A Homo sapiens
1.4.3.4 1.9
-
 kynuramine MAO-A Homo sapiens
1.4.3.4 18.2 20.8 Phenylethylamine MAO-B Bos taurus