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Literature summary extracted from

  • St.John, G.; Brot, N.; Ruan, J.; Erdjument-Bromage, H.; Tempst, P.; Weissbach, H.; Nathan, C.
    Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates (2001), Proc. Natl. Acad. Sci. USA, 98, 9901-9906.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 gene msrA, DNA and amino acid sequence determination and analysis, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates Mycobacterium tuberculosis
1.8.4.11 gene msrA, expression in an msrA-deficient Escherichia coli mutant strain Tn903::msrA conferring resistance against oxidative damage from reactive nitrogen intermediates Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 additional information Escherichia coli MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates ?
-
 ?
1.8.4.11 additional information Mycobacterium tuberculosis MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates ?
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Mycobacterium tuberculosis stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Escherichia coli
-
 gene msrA, strain MC1061
-
1.8.4.11 Mycobacterium tuberculosis
-
 gene msrA, strains CB3.3, 1254, and H37Rv
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.11 additional information
-
 activity in wild-type and recombinant strain Escherichia coli
1.8.4.11 additional information
-
 activity in wild-type strain and recombinant Escherichia coli strain Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 additional information MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates Escherichia coli ?
-
 ?
1.8.4.11 additional information MsrA protects the bacterium against oxidative damage from reactive nitrogen intermediates Mycobacterium tuberculosis ?
-
 ?
1.8.4.11 N-acetyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Escherichia coli N-acetyl-L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.11 N-acetyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Mycobacterium tuberculosis N-acetyl-L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.11 N-acetyl-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Escherichia coli N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 N-acetyl-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mycobacterium tuberculosis N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mycobacterium tuberculosis peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.4.11 ? x * 21000-27000, about, recombinant MsrA, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 MsrA
-
 Escherichia coli
1.8.4.11 MsrA
-
 Mycobacterium tuberculosis
1.8.4.11 peptide methionine sulfoxide reductase
-
 Escherichia coli
1.8.4.11 peptide methionine sulfoxide reductase
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 dithiothreitol
-
 Escherichia coli
1.8.4.11 dithiothreitol
-
 Mycobacterium tuberculosis
1.8.4.11 thioredoxin
-
 Escherichia coli
1.8.4.11 thioredoxin
-
 Mycobacterium tuberculosis