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Literature summary extracted from

  • Steffens, P.; Nagakura, N.; Zenk, M.H.
    The berberine bridge forming enzyme in tetrahydroprotoberberine synthesis (1984), Tetrahedron Lett., 25, 951-952.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.3.3 dithioerythritol 50% inhibition at 4 mM Berberis beaniana
1.21.3.3 o-phenanthroline 50% inhibition at 0.006 mM Berberis beaniana

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.3.3 0.00014
-
 (S)-reticuline
-
 Berberis beaniana

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.21.3.3 49000
-
 gel filtration Berberis beaniana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.3 (S)-reticuline + O2 Berberis beaniana
-
 (S)-scoulerine + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.3 Berberis beaniana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.3 (R,S)-laudanosoline + O2 specific for the (S)-enantiomer Berberis beaniana ? + H2O2
-
 ?
1.21.3.3 (S)-protosinomenine + O2
-
 Berberis beaniana ? + H2O2
-
 ?
1.21.3.3 (S)-reticuline + O2
-
 Berberis beaniana (S)-scoulerine + H2O2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.3.3 8.9
-
-
 Berberis beaniana