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Literature summary extracted from

  • Mahuran, D.J.
    Characterization of human placental beta-hexosaminidase I2: Proteolytic processing intermediates of hexosaminidase A (1990), J. Biol. Chem., 265, 6794-6799.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.52 lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.52 66000
-
 major Hex I2 form: alpha, beta, 1 * 66000 + 1 * 66000, beta chain 2 residues short of being identical to alpha chain, SDS-PAGE Homo sapiens
3.2.1.52 130000
-
 Hex I2, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O Homo sapiens
-
 N-acetyl-D-hexosamines
-
 ?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
3.2.1.52 dithiothreitol reduction, produces fragments of 63000, 56000, 36000 and 28000 Da Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.52 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.2.1.52 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.52 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.52 N-acetyl-beta-D-hexosaminides + H2O
-
 Homo sapiens N-acetyl-D-hexosamines
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.52 dimer Hex A: alpha beta, Hex B: beta beta Homo sapiens
3.2.1.52 dimer major Hex I2 form: alpha, beta, 1 * 66000 + 1 * 66000, beta chain 2 residues short of being identical to alpha chain, SDS-PAGE Homo sapiens
3.2.1.52 More
-
 Homo sapiens