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Literature summary extracted from

  • Tone, Y.; Kitagawa, H.; Imiya, K.; Oka, S.; Kawasaki, T.; Sugahara, K.
    Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans (1999), FEBS Lett., 459, 415-420.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.135 expression of full-length GlcAT-I in COS-1 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.135 0.0293
-
 UDPglucuronate
-
 Homo sapiens
2.4.1.135 0.0804
-
 Galbeta(1-3)Galbeta(1-4)Xyl
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.135 Cu2+ divalent cations essential, 2.7% as effective as Mn2+ Homo sapiens
2.4.1.135 Mg2+ divalent cations essential, 5.5% as effective as Mn2+ Homo sapiens
2.4.1.135 Mn2+ divalent cations essential, Mn2+ exhibits highest activity, optimal concentration: 2 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.135 additional information Homo sapiens the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans ?
-
 ?
2.4.1.135 UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl Homo sapiens high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.135 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.135 additional information negligible activity with Galbeta(1-3)galbeta1-O-benzyl, galbeta(1-4)GlcNAc and galbeta(1-4)Glc Homo sapiens ?
-
 ?
2.4.1.135 additional information the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans Homo sapiens ?
-
 ?
2.4.1.135 UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
-
 Homo sapiens UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
-
 ?
2.4.1.135 UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope Homo sapiens UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.135 6.5
-
-
 Homo sapiens