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Literature summary extracted from

  • Rydström, J.
    Energy-linked nicotinamide nucleotide transhydrogenases (1977), Biochim. Biophys. Acta, 463, 155-184.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.1.2 Lipids
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.1.2 5'-AMP
-
 Bos taurus
1.6.1.2 5'-AMP
-
 Escherichia coli
1.6.1.2 5'-AMP
-
 Rattus norvegicus
1.6.1.2 Ca2+
-
 Bos taurus
1.6.1.2 Ca2+
-
 Rattus norvegicus
1.6.1.2 Mg2+
-
 Bos taurus
1.6.1.2 Mg2+
-
 Rattus norvegicus
1.6.1.2 Mg2+
-
 Rhodospirillum rubrum
1.6.1.2 Mn2+
-
 Bos taurus
1.6.1.2 Mn2+
-
 Rattus norvegicus
1.6.1.2 triiodothyronine
-
 Bos taurus
1.6.1.2 triiodothyronine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.1.2 0.0065
-
 NADP+ energy-linked reaction Bos taurus
1.6.1.2 0.009
-
 NADH nonenergy-linked reaction Bos taurus
1.6.1.2 0.0126
-
 NADH energy-linked reaction Bos taurus
1.6.1.2 0.02
-
 NADPH nonenergy-linked reaction Bos taurus
1.6.1.2 0.02
-
 NADPH energy-linked reaction Bos taurus
1.6.1.2 0.028
-
 NAD+ nonenergy-linked reaction Bos taurus
1.6.1.2 0.04
-
 NADP+ nonenergy-linked reaction Bos taurus
1.6.1.2 0.0435
-
 NAD+ energy-linked reaction Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.6.1.2 250000
-
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Bos taurus
-
-
-
1.6.1.2 Escherichia coli
-
-
-
1.6.1.2 Rattus norvegicus
-
-
-
1.6.1.2 Rhodospirillum rubrum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.1.2 overview of early procedures Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.6.1.2 NADPH + NAD+ = NADP+ + NADH mechanism Rattus norvegicus
a
1.6.1.2 NADPH + NAD+ = NADP+ + NADH mechanism Bos taurus
a
1.6.1.2 NADPH + NAD+ = NADP+ + NADH mechanism Rhodospirillum rubrum
a
1.6.1.2 NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Escherichia coli
a
1.6.1.2 NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Bos taurus
a
1.6.1.2 NADPH + NAD+ = NADP+ + NADH enzyme is stereospecific for the 4A hydrogen of NADH and the 4B hydrogen of NADPH Rhodospirillum rubrum
a

Renatured (Commentary)

EC Number Renatured (Comment) Organism
1.6.1.2 reconstitution into liposomes Rattus norvegicus
1.6.1.2 reconstitution into liposomes Bos taurus
1.6.1.2 reconstitution into liposomes Rhodospirillum rubrum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Escherichia coli NAD+ + NADPH
-
 ?
1.6.1.2 NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Rattus norvegicus NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Bos taurus NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+ specific for 4A site of NADH, i.e. pro-R hydrogen and 4B site of NADPH, i.e. pro-S hydrogen Rhodospirillum rubrum NAD+ + NADPH
-
 r
1.6.1.2 NADH + thio-NADP+
-
 Rattus norvegicus NAD+ + thio-NADPH
-
 r
1.6.1.2 NADH + thio-NADP+
-
 Bos taurus NAD+ + thio-NADPH
-
 r
1.6.1.2 NADH + thio-NADP+
-
 Rhodospirillum rubrum NAD+ + thio-NADPH
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.1.2 NAD+
-
 Escherichia coli
1.6.1.2 NAD+
-
 Rattus norvegicus
1.6.1.2 NAD+
-
 Bos taurus
1.6.1.2 NAD+
-
 Rhodospirillum rubrum
1.6.1.2 NADH
-
 Escherichia coli
1.6.1.2 NADH
-
 Rattus norvegicus
1.6.1.2 NADH
-
 Bos taurus
1.6.1.2 NADH
-
 Rhodospirillum rubrum
1.6.1.2 NADP+
-
 Escherichia coli
1.6.1.2 NADP+
-
 Rattus norvegicus
1.6.1.2 NADP+
-
 Bos taurus
1.6.1.2 NADP+
-
 Rhodospirillum rubrum
1.6.1.2 NADPH
-
 Escherichia coli
1.6.1.2 NADPH
-
 Rattus norvegicus
1.6.1.2 NADPH
-
 Bos taurus
1.6.1.2 NADPH
-
 Rhodospirillum rubrum