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Literature summary extracted from
- Heterogeneity of hepatic nicotine oxidase (1982), Biochim. Biophys. Acta, 715, 254-257.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.5.99.4 | microsome | - |
Rattus norvegicus | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.99.4 | Rattus norvegicus | - |
seven-week-old, male, Wistar | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.5.99.4 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.5.99.4 | 0.000514 | 0.000888 | variation caused by pre-treatment with 3-methylcholanthrene, beta-naphthoflavone or phenobarbital | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.99.4 | nicotine + acceptor + H2O | - |
Rattus norvegicus | 6-hydroxynicotine + reduced acceptor | - |
? |  |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.5.99.4 | 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.5.99.4 | 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.99.4 | cytochrome P450 | small content to nicotine oxidation, cytochrome P-450-linked monooxygenase | Rattus norvegicus | |
| 1.5.99.4 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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