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Literature summary extracted from

  • Wang, Y.; Devereux, W.; Woster, P.M.; Stewart, T.M.; Hacker, A.; Casero, R.A., Jr.
    Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure (2001), Cancer Res., 61, 5370-5373.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.3.16
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.16 N1,N4-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL72527 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.16 0.018
-
 spermine 37°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.3.16 62000
-
 x * 62000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.3.16 additional information Homo sapiens PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Homo sapiens Q9NWM0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 additional information PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity Homo sapiens ?
-
 ?
1.5.3.16 spermine + O2 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.5.3.16 ? x * 62000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.5.3.16 PAOh1
-
 Homo sapiens