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Literature summary extracted from

  • Fellows, F.C.I.; Lewis, M.H.R.
    Lysine metabolism in mammals (1973), Biochem. J., 136, 329-334.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.5.1.8 medicine hyperlysinemia: genetic disease, deficiency of lysine-ketoglutarate reductase results in extreme elevations of serum lysine Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.8 mitochondrion
-
 Homo sapiens 5739
-
1.5.1.8 mitochondrion
-
 Rattus norvegicus 5739
-
1.5.1.8 mitochondrion
-
 Sus scrofa 5739
-
1.5.1.8 mitochondrion
-
 Bos taurus 5739
-
1.5.1.8 mitochondrion
-
 Ovis aries 5739
-
1.5.1.8 mitochondrion
-
 Canis lupus familiaris 5739
-
1.5.1.8 mitochondrion
-
 Felis catus 5739
-
1.5.1.9 mitochondrion
-
 Homo sapiens 5739
-
1.5.1.9 mitochondrion
-
 Rattus norvegicus 5739
-
1.5.1.9 mitochondrion
-
 Sus scrofa 5739
-
1.5.1.9 mitochondrion
-
 Bos taurus 5739
-
1.5.1.9 mitochondrion
-
 Ovis aries 5739
-
1.5.1.9 mitochondrion
-
 Canis lupus familiaris 5739
-
1.5.1.9 mitochondrion
-
 Felis catus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Homo sapiens lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Sus scrofa lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Bos taurus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Ovis aries lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Canis lupus familiaris lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Felis catus lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Homo sapiens important role in the degradation of lysine N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH Rattus norvegicus Wistar lysine catabolism N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Homo sapiens involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Rattus norvegicus involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Sus scrofa involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Bos taurus involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Ovis aries involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Canis lupus familiaris involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Felis catus involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Rattus norvegicus Wistar involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.8 Bos taurus
-
-
-
1.5.1.8 Canis lupus familiaris
-
 mongrels
-
1.5.1.8 Felis catus
-
 tabby
-
1.5.1.8 Homo sapiens
-
-
-
1.5.1.8 Ovis aries
-
-
-
1.5.1.8 Rattus norvegicus
-
 Wistar strain
-
1.5.1.8 Rattus norvegicus Wistar
-
 Wistar strain
-
1.5.1.8 Sus scrofa
-
-
-
1.5.1.9 Bos taurus
-
-
-
1.5.1.9 Canis lupus familiaris
-
-
-
1.5.1.9 Felis catus
-
-
-
1.5.1.9 Homo sapiens
-
-
-
1.5.1.9 Ovis aries
-
-
-
1.5.1.9 Rattus norvegicus
-
-
-
1.5.1.9 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.8 liver
-
 Homo sapiens
-
1.5.1.8 liver
-
 Rattus norvegicus
-
1.5.1.8 liver
-
 Sus scrofa
-
1.5.1.8 liver
-
 Bos taurus
-
1.5.1.8 liver
-
 Ovis aries
-
1.5.1.8 liver
-
 Canis lupus familiaris
-
1.5.1.8 liver
-
 Felis catus
-
1.5.1.9 liver
-
 Homo sapiens
-
1.5.1.9 liver
-
 Rattus norvegicus
-
1.5.1.9 liver
-
 Sus scrofa
-
1.5.1.9 liver
-
 Bos taurus
-
1.5.1.9 liver
-
 Ovis aries
-
1.5.1.9 liver
-
 Canis lupus familiaris
-
1.5.1.9 liver
-
 Felis catus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.8 additional information
-
-
 Homo sapiens
1.5.1.8 additional information
-
-
 Rattus norvegicus
1.5.1.8 additional information
-
-
 Sus scrofa
1.5.1.8 additional information
-
-
 Bos taurus
1.5.1.8 additional information
-
-
 Ovis aries
1.5.1.8 additional information
-
-
 Canis lupus familiaris
1.5.1.8 additional information
-
-
 Felis catus
1.5.1.9 0.0045
-
-
 Bos taurus
1.5.1.9 0.0047
-
-
 Homo sapiens
1.5.1.9 0.005
-
-
 Rattus norvegicus
1.5.1.9 0.0054
-
-
 Ovis aries
1.5.1.9 0.0055
-
-
 Canis lupus familiaris
1.5.1.9 0.0058
-
-
 Sus scrofa
1.5.1.9 0.0069
-
-
 Felis catus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Sus scrofa N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Bos taurus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Ovis aries N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Canis lupus familiaris N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Felis catus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Rattus norvegicus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Sus scrofa N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Bos taurus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Ovis aries N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Canis lupus familiaris N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Felis catus N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH important role in the degradation of lysine Homo sapiens N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH enzyme catalyzes lysine degradation to saccharopine Rattus norvegicus Wistar N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine ?
1.5.1.8 L-lysine + 2-oxoglutarate + NADPH lysine catabolism Rattus norvegicus Wistar N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O saccharopine is a key intermediate in the degradative pathway of lysine metabolism ?
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Homo sapiens L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Rattus norvegicus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Sus scrofa L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Bos taurus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Ovis aries L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Canis lupus familiaris L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Felis catus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Homo sapiens L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Rattus norvegicus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Sus scrofa L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Bos taurus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Ovis aries L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Canis lupus familiaris L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Felis catus L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Rattus norvegicus Wistar L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Rattus norvegicus Wistar L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.8 NADPH
-
 Homo sapiens
1.5.1.8 NADPH
-
 Rattus norvegicus
1.5.1.8 NADPH
-
 Sus scrofa
1.5.1.8 NADPH
-
 Bos taurus
1.5.1.8 NADPH
-
 Ovis aries
1.5.1.8 NADPH
-
 Canis lupus familiaris
1.5.1.8 NADPH
-
 Felis catus
1.5.1.9 NAD+
-
 Homo sapiens
1.5.1.9 NAD+
-
 Rattus norvegicus
1.5.1.9 NAD+
-
 Sus scrofa
1.5.1.9 NAD+
-
 Bos taurus
1.5.1.9 NAD+
-
 Ovis aries
1.5.1.9 NAD+
-
 Canis lupus familiaris
1.5.1.9 NAD+
-
 Felis catus